Tritiated imipramine binding to whole platelets was measured in 16 chronic pain patients who were free from major depression, and in a control group.

The maximum binding was significantly lower in chronic pain patients than in the control group, whereas the binding affinity was not significantly different.

Twelve patients were treated with mianserin for 21 days; this produced a significant improvement in the mean scores for pain (evaluated with the McGill Questionnaire) and depressive symptoms (assessed with the Zung Self-Rating Scale). Leggi tutto...