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Cerebral tryptophan metabolism in humans in relation to malignant pain.

The authors investigated the cerebral metabolism of tryptophan in patients suffering from malignant pain by means of CSF dosage of tryptophan (Trp), 5-hydroxytryptophan (5-HTP), serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA).

The level of 5-HIAA in patients with pain was 66.48 +/- 13.67 ng/ml, while in those without pain was 25.05 +/- 13.25 ng/ml; the difference was statistically significant, p = 0.001. Leggi tutto...

Autori: 
Ceccherelli F, Costa C, Ischia S, Ischia A, Giron G, Allegri G.
Pubblicato su: 
Funct Neurol. 1989 Oct-Dec;4(4):341-53.

The influence of acupuncture on blood serum levels of tryptophan in healthy volunteers subjected to ketamine anesthesia.

Ketamine, 2-(0-chlorophenyl)-2-(methylamino)-cyclohexanone, is a general anesthetic which on awakening produces psychic disturbance correlated with the metabolism of serotonin.

Since it is know that acupuncture increases cerebral serotonin, the blood levels of total and free tryptophan, its precursor, were studied in healthy volunteers to find out if the anti-hallucinatory action of acupuncture is dependent on an increase in cerebral serotonin.

Autori: 
Costa C, Ceccherelli F, Ambrosio F, Baron P, De Antoni A, Vanzan S, Allegri G, Manani G.
Pubblicato su: 
Acupunct Electrother Res. 1982;7(2-3):123-32.
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